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Prof. Shih-Jung Liu

Shih-Jung Liu  
Research area: Polymer materials and processing; Biomaterials
Laboratory: Biomaterials  Lab
Tel: +886-3-2118800 ext. 5347 (Office), 5724 (Lab)

- Ph.D., University of Wisconsin-Madison, USA (1992)
- B.S., National Taiwan University, Taiwan (1986)
- Associate Professor, Chang Gung University, Taiwan (1993-2001)
- Visiting Professor, Aachen University of Technology, Germany (2000)
- Visiting Professor, Tokyo Institute of Technology, Japan (1998)
- Post-Doctoral Research Fellow, McMaster University, Canada (1993)
Honor and Awards:
Annual Morand Lamble Awardee, International Polymer Processing Society (2008)
Selected Publications:
  1. C.H. Lee, S.C. Huang, K.C. Hung, C.J. Chao, S.J. Liu*. Enhanced Diabetic Wound Healing Using Electrospun Biocompatible PLGA-Based Saxagliptin Fibrous Membranes. Nanomaterials, 12, 3740 (2022) (IF=5.719) (SCI) DOI: 10.3390/nano12213740.
  2. D. Lee, Y.K. Lin, S.C. Hsu, Y.L. Tang, S.J. Liu*. Factors determining the flow erosion/part deformation of film insert molded thermoplastic products. International Polymer Processing, 37(4), 442 451 (2022) (IF=0.824) (SCI) 指導作者 DOI: 10.1515/ipp-2021-4194.
  3. Y.H. Yu, S.J. Shen, Y.H. Hsu, Y.C. Chou, P.C. Yu, S.J. Liu*. Tri-layered doxycycline, collagen and bupivacaine loaded poly(lactic-co-glycolic acid) nanofibrous scaffolds for tendon rupture repair. Polymers, 14, 2659 (2022) (IF=4.329) (SCI) 指導作者 DOI: 10.3390/polym14132659.
  4. C.H. Lee, M.J. Hsieh, J. Roth, X. Fu, C.H. Lu, K.C. Hung, C.C. Kuo, S.J. Liu*. Hybrid core-shell nanofibrous scaffolds/stent delivery angiotensin II receptor blocker to treat diabetic artery disease. ACS Applied Polymer Materials, 4, 4199-4207 (2022) (IF=4.089) (SCI)指導作者 DOI: 10.1021/acsapm.2c00186.
  5. Y.H. Hsu, Y.H. Yu, D. Lee, Y.C. Chou, C.K. Wu, C.J. Lu, S.J. Liu*. Pharmaceutical-eluting hybrid degradable hydrogel/microparticle loaded sacs for finger joint interpositional arthroplasty. Biomaterials Advances, 137, 212846 (2022) (IF=7.328) (SCI) 指導作者 DOI: 10.1016/j.bioadv.2022.212846.
  6. C.J. Weng, Y.C. Wu, M.Y. Hsu, F.P. Chang, S.J. Liu*. Electrospun, resorbable, drug-eluting, nanofibrous membranes promote healing of allograft tendons. Membranes, 12, 529 (2022) (IF=4.106) (SCI)指導作者 DOI: 10.3390/membranes12050529
  7. C.J. Weng, C.T. Liao, M.Y. Hsu, F.P. Chang, S.J. Liu*. Simvastatin-loaded nanofibrous membrane efficiency on the repair of Achilles tendons. International Journal of Nanomedicine, 17, 1171-1184 (2022) (IF=6.400) (SCI) 指導作者 DOI: 10.2147/IJN.S353066.
  8. K.S. Liu, W.H. Chen, C.H. Lee, Y.F. Su, Y.W. Liu, S.J. Liu*. Novel Biodegradable 3D-printed Analgesics-eluting-nanofibers Incorporated Nuss Bars for Therapy of Pectus Excaratum. International Journal of Molecular Sciences, 23, 2265 (2022) (IF=5.924) (SCI)指導作者 DOI: 10.3390/ijms23042265.
  9. S.J. Shen, Y.C. Chou, S.C. Hsu, Y.T. Lin, C.J. Lu, S.J. Liu*. Fabrication of ropivacaine/dexamethasone-eluting microparticles via electrospraying technique for postoperational pain control. Polymers, 14, 702 (2022) (IF=4.329) (SCI) 指導作者 DOI: 10.3390/polym14040702.
  10. P.Y. Chou, D. Lee, C.C. Weng, R.C. Wu, C.T. Liao, S.J. Liu*. Bone Morphogenetic Protein-, Antimicrobial Agent-, and Analgesic-Incorporated Nanofibrous Scaffolds for the Therapy of Alveolar Clefts. Pharmaceutics, 14, 374 (2022) (IF=6.321) (SCI)指導作者DOI: 10.3390/pharmaceutics14020374.
  11. P.Y. Chou, D. Lee, S.H. Chen, C.T. Liao, L.J. Lo, S.J. Liu*. 3D-printed/electrospun bioresorbable nanofibrous drug-eluting cuboid frames for repair of alveolar bone defects. International Journal of Pharmaceutics, 615, 121497 (2022) (IF=5.875) (SCI)指導作者DOI: 10.1016/j.ijpharm.2022.121497.
  12. C.H. Lee, K.S. Liu, J.G. Roth, K.C. Hung, Y.W. Liu, S.H. Wang, C.C. Kuo, S.J. Liu*. Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia. Pharmaceutics, 13, 1756 (2021) (IF=6.321) (SCI) 指導作者 DOI: 10.3390/pharmaceutics13111756.
  13. S. Morelli, S.J. Liu, L. De Bartolo. Membrane Systems for Tissue Engineering 2020. Membranes, 11, 763 (2021) (IF=4.106) (SCI). DOI: 10.3390/membranes11100763.
  14. Y.H. Yu, Y.T. Lin, Y.H. Hsu, Y.C. Chou, S.W.N. Ueng, S.J. Liu*. Biodegradable Antimicrobial Agent/Analgesic/Bone Morphogenetic Protein-Loaded Nanofibrous Fixators for Bone Fracture Repair. International Journal of Nanomedicine, 16, 5357-5370 (2021) (IF=6.400) (SCI) 指導作者 DOI: 10.2147/IJN.S325885.
  15. Y.P. Chen, T.S. Lo, Y.T. Lin, Y.H. Chien, C.J. Lu, S.J. Liu*. Fabrication of Drug-Eluting Polycaprolac-tone/Poly(Lactic-co-Glycolic Acid) Prolapse Mats Using Solution-Extrusion 3D Printing and Coaxial Electrospinning Techniques. Polymers, 13, 2295 (2021) (IF=4.329) (SCI) 指導作者 DOI: 10.3390/polym13142295.
  16. Y.Y. Tseng, T.Y. Chen, S.J. Liu*. Role of polymeric local drug delivery in multimodal treatment of malignant glioma: A review. International Journal of Nanomedicine, 16, 45974614 (2021) (IF=6.400) (SCI)指導作者 DOI: 10.2147/IJN.S309937.
  17. M.Y. Hsu, C.H. Hsieh, Y.T. Huang, S.Y. Chu, C.M. Chen, W.J. Lee, S.J. Liu*. Enhanced paclitaxel efficacy to suppress triple-negative breast cancer progression using metronomic chemotherapy with a controlled release system of electrospun poly-D-L-lactide-co-glycolide (PLGA) nanofibers. Cancers, 13, 3350 (2021) (IF=6.639) (SCI) 指導作者 DOI: 10.3390/cancers13133350.
  18. K.S. Liu, C.W. Kao, Y.Y. Tseng, S.K. Chen, Y.T. Lin, C.J. Lu, S.J. Liu*. Assessment of antimicrobial agents, analgesics, and epidermal growth factors-embedded anti-adhesive poly(lactic-co-glycolic acid) nanofibrous membranes: In vitro and in vivo studies. International Journal of Nanomedicine, 16, 4471-4480 (2021) (IF=6.400) (SCI) 指導作者 DOI: 10.2147/IJN.S318083.
  19. Y. Srithep, T. Akkaprasa, D. Pholharn, J. Morris, S.J. Liu, P. Patrojanasophon, T. Ngawhirunpat. Metronidazole-loaded polylactide stereocomplex electrospun nanofibers for treatment of periodontal disease. Journal of Drug Delivery Science and Technology, 64, 102582 (2021) (IF=2.734) (SCI). DOI: 10.1016/j.jddst.2021.102582.
  20. Y.H. Yu, S.J. Liu*. Polyetheretherketone for orthopedic applications: A review. Current Opinion in Chemical Engineering, 1, 100687 (2021) (IF=4.008) (SCI) 指導作者 DOI: 10.1016/j.coche.2021.100687.
  21. T.C. Yang, S.J. Liu, W.L. Lo, S.M. Chen, Y.L. Tang, Y.Y. Tseng. Enhanced anti-tumor activity in mice with temozolomide-resistant human glioblastoma cell line-derived xenograft using SN-38-incorporated polymeric microparticle. International Journal of Molecular Sciences, 22, 5557 (2021) (IF=4.556) (SCI). DOI: 10.3390/ijms22115557.
  22. T.Y. Yu, J.W.S. Pang, L.P. Lin, J.W. Cheng, S.J. Liu, W.C. Tsai. Platelet-rich plasma releasate promotes early healing in tendon after acute injury. The Orthopaedic Journal of Sports Medicine, 9(4), 2325967121990377 (2021) (IF=2.492) (SCI). DOI: 10.1177/2325967121990377.
  23. D. Lee, M.Y. Hsu, Y.L. Tang, S.J. Liu*. Manufacture of binary nanofeatured polymeric films using nanosphere lithography and ultraviolet roller imprinting. Materials, 14, 1669 (2021) (IF=3.057) (SCI) 指導作者 DOI: 10.3390/ma14071669.
  24. C.J. Weng, Y.C. Wu, S.J. Liu*. Manufacture of unitary/binary ordered arrays employing self-assembled nanocolloid lithography. Japanese Journal of Applied Physics, 60, 036502 (2021) (IF=1.376) (SCI)指導作者 DOI: 10.35848/1347-4065/abe817.
  25. D. Lee, Y.L. Tang, S.J. Liu*. Fast Fabrication of Nanostructured Films Using Nanocolloid Lithography and UV Soft Mold Roller Embossing: Effects of Processing Parameters. Polymers, 13, 405 (2021) 指導作者 DOI: 10.3390/polym13030405.
  26. P.Y. Chou, Y.C. Chou, Y.H. Lai, Y.T. Lin, C.J. Lu, S.J. Liu*, Fabrication of Drug-Eluting Nano-Hydroxylapatite Filled Polycaprolactone Nanocomposites Using Solution-Extrusion 3D Printing Technique. Polymers, 13, 318 (2021) (IF=3.426) (SCI) 指導作者 DOI: 10.3390/polym13030318.
  27. S.J. Shen, D. Lee, Y.C. Wu, S.J. Liu*. Binary self-assembly of nanocolloidal arrays using concurrent and sequential spin-coating techniques. Materials, 14, 274 (2021) (IF=3.057) (SCI) 指導作者 DOI: 10.3390/ma14020274.
  28. C.H. Lee, K.S. Liu, C.W. Cheng, E.C. Chan, K.C. Hung, M.J. Hsieh, S.H. Chang, X. Fu, J.H. Juang, I.C. Hsieh, M.S. Wen, S.J. Liu*. Co-delivery of sustainable anti-microbial agents and platelet-derived growth factor via biodegradable nanofibers for repair of diabetic infectious wounds. ACS Infectious Diseases, 6, 2688-2697 (2020) (IF=4.614) (SCI) 指導作者 DOI: 10.1021/acsinfecdis.0c00321.
  29. Y.Y. Tseng, T.C. Yang, S.M. Chen, S.T. Yang, Y.L. Tang, S.J. Liu*. Injectable SN-38-embedded polymeric microparticles promote antitumor efficacy against malignant glioma in an animal model. Pharmaceutics, 12, 479 (2020) (IF=4.773) (SCI) 指導作者 DOI: 10.3390/pharmaceutics12050479.
  30. J.M. Chen, D. Lee, J.W. Yang, S.H. Lin, Y.T. Lin, S.J. Liu*. Solution-extrusion additive manufacturing of biodegradable polycaprolactone. Applied Sciences, 10, 3189 (1-14) (2020) (IF=2.217) (SCI) 指導作者 DOI: 10.3390/app10093189.
  31. M.Y. Hsu, Y.T. Huang, C.J. Weng, C.M. Chen, Y.F. Su, S.Y. Chu, J.H. Tseng, R.C. Wu, S.J. Liu*. Preparation and in vitro/in vivo evaluation of doxorubicin-loaded poly[lactic-co-glycol acid] microspheres using electrospray method for sustained drug delivery and potential intratumoral injection. Colloids and Surfaces B: Biointerfaces, 190, 110937 (2020) (IF=3.973) (SCI) 指導作者 DOI: 10.1016/j.colsurfb.2020.110937.
  32. Y.H. Yu, D. Lee, Y.H. Hsu, Y.C. Chou, S.W.N. Ueng, C.K. Chen, S.J. Liu*. A three-dimensional printed polycaprolactone scaffold combined with co-axially electrospun vancomycin/ceftazidime/bone morphological protein-2 sheath-core nanofibers for the repair of segmental bone defects during the Masquelet procedure. International Journal of Nanomedicine, 15, 913 925 (2020) (IF=4.383) (Sth-Core Nanofibers for the Repair of Segmental Bone Defects During the Masquelet Procedure">10.2147/IJN.S238478.
  33. J.M. Chen, K.C. Liu, W.L. Yeh, J.C. Chen, S.J. Liu*. Sustained Release of Levobupivacaine, Lidocaine and Acemetacin from Electrosprayed Microparticles: In vitro and in vivo studies. International Journal of Molecular Sciences, 21, 1093 (1-15) (2020) (IF=4.183) (SCI) 指導作者 DOI: 10.3390/ijms21031093.
  34. Y.Y. Tseng, C.K. Kao, K.S. Liu, Y.L. Tang, Y.W. Liu, S.J. Liu*. Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles. Pharmaceutics, 12, 91 (2020) (IF=4.773) (SCI)指導作者 DOI: 10.3390/pharmaceutics12020091.
  35. J.M. Chen, Y.Y. Tseng, D. Lee, Y.T. Lin, S.H. Lin, T.Y. Lee, S.J. Liu*, H. Ito. A robust experimental DOI: 10.3390/app10020509.
  36. C.J. Weng, D. Lee, J. Ho, S.J. Liu*. Doxycycline-embedded nanofibrous membranes help promote healing of tendon rupture. International Journal of Nanomedicine, 15, 125-136 (2020) (IF=4.383) DOI: 10.2147/IJN.S217697.
  37. C.H. Lee, K.C. Hung, M.J. Hsieh, S.H. Chang, J.H. Juang, I.C. Hsieh, M.S. Wen, S.J. Liu*. Core-shell insulin-loaded nanofibrous scaffolds for repairing diabetic wounds. Nanomedicine: Nanotechnology, Biology, and Medicine 24,102123 (2020) (IF=5.570) (SCI) 指導作者 DOI: 10.1016/j.nano.2019.102123.
  38. Y.H. Hsu, H.Y. Chen, J.C. Chen, Y.H. Yu, Y.C. Chou, S.W.N. Ueng*, S.J. Liu*. Resorbable beads provide extended release of antifungal medication: In vitro and in vivo analyses. Pharmaceutics, 11, 550 (2019) (IF=4.773) (SCI)指導作者 DOI: 10.3390/pharmaceutics11110550.
  39. S.J. Liu, S.T. Yang, S.M. Chen, Y.C. Huang, W.H. Lee, J. Ho, Y.C. Chen, Y.Y. Tseng. Novel multi-drugs incorporated hybrid-structured nanofibers enhance alkylating agents activity in malignant gliomas. Therapeutic Advances in Medical Oncology, 11, 1-17 (2019) (IF=5.670). DOI: 10.1177/1758835919875555.
  40. C.H. Lee, M.J. Hsieh, S.H. Chang, K.C. Hung, C.J. Wang, M.Y. Hsu, J.H. Juang, I.C. Hsien, M. S. Wen, S.J. Liu*. Nanofibrous vildagliptin-eluting stents enhancere-endothelialization and reduce neointimal formation in diabetes: in vitro and in vivo. International Journal of Nanomedicine, 14, 7503 7513 (2019) (IF=4.383) (SCI)指導作者 DOI: 10.2147/IJN.S211898.
  41. C.W. Kao, Y.Y. Tseng, K.S. Liu, J.C. Chen, H.L. He, Y.C. Kau, S.J. Liu*, Anesthetics and human epidermal growth factor incorporated into anti-adhesive nanofibers provide sustained pain relief and promote healing of surgical wounds. International Journal of Nanomedicine, 14, 4007 4016 (2019) (IF=4.383) (SCI)指導作者 DOI: 10.2147/IJN.S202402.
  42. M.Y. Hsu, C.H. Feng, Y.W. Liu, S.J. Liu*, An orthogonal model to study the effect of electrospraying parameters on the morphology of poly (D,L)-lactide-co-glycolide (PLGA) particles, Applied Sciences, 9, 1077 (2019) (IF=1.689) (SCI) 指導作者 DOI: 10.3390/app9061077.
  43. Y.P. Chen, H.Y. Liu, Y.W. Liu, T.Y. Lee, S.J. Liu*, Determination of Electrospinning Parameters Strength in Poly(D,L)-lactide-co-glycolide Micro/Nanofibers Diameter Tailoring, Journal of Nanomaterials, 2019, 2626085-8 (2019) (IF=2.207) (SCI) 指導作者 DOI: 10.1155/2019/2626085.
  44. Y.P. Chen, Y.W. Liu, D. Lee, J.T. Qiu, T.Y. Lee, S.J. Liu*, Biodegradable Andrographolide-eluting Nanofibrous Membranes for the Treatment of Cervical Cancer, International Journal of Nanomedicine, 14, 421 429 (2019) (IF=4.383) (SCI) 指導作者 DOI: 10.2147/IJN.S186714.
  45. S.J. Liu, T.C. Yang, S.T. Yang, Y.C. Chen, Y.Y. Tseng, Biodegradable hybrid-structured nanofibrous membrane supported chemoprotective gene therapy enhances chemotherapy tolerance and efficacy in malignant glioma rats, Artificial Cells, Nanomedicine and Biotechnology, 46, S515-S526 (2018) (IF=5.605) (SCI). DOI: 10.1080/21691401.2018.1460374./span>
  46. K.S. Liu, W.H. Chen, C.H. Lee, Y.F. Su, S.J. Liu*, Extended Pain Relief Achieved by Analgesic-eluting Biodegradable Nanofibers in the Nuss Procedure: In Vitro and In Vivo Studies, International Journal of Nanomedicine, 13, 8355–8364 (2018) (IF=4.383) (SCI) 指導作者 DOI: 10.2147/IJN.S189505.
  47. Y.H. Yu, R.C. Wu, D. Lee, C.K. Chen, S.J. Liu*, Artificial membrane induced by novel biodegradable nanofibers in the Masquelet procedure for treatment of segmental bone defects, Journal of Nanomaterials, 2018, 8246571-8 (2018) (IF=2.207) (SCI) 指導作者 DOI: 10.1155/2018/8246571.
  48. C.H. Lee, M.J. Hsieh, S.H. Chang, S.J. Liu*, C.J. Wang, K.C. Hung, Y.H. Yeh, W.J. Chen, I.C. Hsieh, M.S. Wen, Promoting vascular healing using nanofibrous ticagrelor-eluting stents, International Journal of Nanomedicine, 13, 6039-6048 (2018) (IF=4.383) (SCI) 指導作者 DOI: 10.2147/IJN.S166785.
  49. D. Lee, M.Y. Hsu, M.J. Li, Y.W. Liu, S.J. Liu*, C.Y. Liu, H. Ito, Factors affecting the co-axial electrospraying of core–shell-structured poly(d,l-lactide-co-glycolide) microparticles, Japanese Journal of Applied Physics, 57, 116702 (2018) (IF=1.452) (SCI) 指導作者 DOI: 10.7567/JJAP.57.116702V.
  50. Y.H. Hsu, D.W. Chen, M.J. Li, Y.H. Yu, Y.C. Chou, S.J. Liu*, Sustained Delivery of Analgesic and Antimicrobial Agents to Knee Joint by Direct Injections of Electrosprayed Multipharmaceutical-Loaded Nano/Microparticles. Polymers 10, 890-16 (2018) (IF=2.935) (SCI)指導作者 DOI: 10.3390/polym10080890.
  51. C.H. Lee, M.J. Hsieh, S.C. Liu, J.K. Chen, S.J. Liu*, I.C. Hsieh, M.S. Wen, K.C. Hung, Novel Bifurcation Stents Coated with Bioabsorbable Nanofibers with Extended and Controlled Release of Rosuvastatin and Paclitaxel, Materials Science & Engineering C, 88, 61-69 (2018) (IF=4.164) (SCI) 指導作者 DOI: 10.1016/j.msec.2018.02.027.
  52. S.H. Chang, C.H. Lee, Y.H. Ush, S.J. Liu, C.J. Wang, M.Y. Hsu, W.J. Chen, Propylthiouracil-coated biodegradable polymer inhibited neointimal formation and enhanced re-endothelialization after vascular injury, International Journal of Nanomedicine, 13 1761–1771 (2018) (IF=4.383) (SCI). DOI: 10.2147/IJN.S145528.
  53. Y.C. Lin, K.S. Liu, D. Lee, M.J. Li, S.J. Liu*, H. Ito, In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents, Journal of Nanomaterials, 2018, 4943210-7 (2018) (IF=1.871) (SCI) 指導作者 DOI: 10.1155/2018/4943210.